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104550 ACA - CAS 110683-10-8 - Calbiochem

A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.

ACA - CAS 110683-10-8 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: N-(p-Amylcinnamoyl)anthranilic Acid

Primary Target: A2PLA2
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104550
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
110683-10-8C₂₁H₂₃NO₃

Pricing & Availability

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104550-25MG
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      		 Plastic ampoule 25 mg
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      Description
      OverviewA cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.
      Catalogue Number104550
      Brand Family Calbiochem®
      SynonymsN-(p-Amylcinnamoyl)anthranilic Acid
      References
      ReferencesLiu, L., et al. 1999. J. Cell. Biochem. 72, 103.
      Simonsson, E., et al. 1998. Diabetes 47, 1436.
      Konrad, R.J., et al. 1992. Biochim. Biophys. Acta 1135, 215.
      Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 9197.
      Product Information
      CAS number110683-10-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₁H₂₃NO₃
      Chemical formulaC₂₁H₂₃NO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA2PLA2
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      104550-25MG 04055977226461

      Documentation

      ACA - CAS 110683-10-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      ACA - CAS 110683-10-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      104550

      References

      Reference overview
      Liu, L., et al. 1999. J. Cell. Biochem. 72, 103.
      Simonsson, E., et al. 1998. Diabetes 47, 1436.
      Konrad, R.J., et al. 1992. Biochim. Biophys. Acta 1135, 215.
      Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 9197.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2016 JSW
      SynonymsN-(p-Amylcinnamoyl)anthranilic Acid
      DescriptionInhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A2 (PLA2) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.
      FormWhite solid
      CAS number110683-10-8
      Chemical formulaC₂₁H₂₃NO₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityEthanol (10 mg/ml) or DMSO (50 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLiu, L., et al. 1999. J. Cell. Biochem. 72, 103.
      Simonsson, E., et al. 1998. Diabetes 47, 1436.
      Konrad, R.J., et al. 1992. Biochim. Biophys. Acta 1135, 215.
      Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 9197.