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287891 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem

A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC₅₀ = 6 µM).

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: 5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII

Primary Target: casein kinase II
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287891
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53-85-0C₁₂H₁₂Cl₂N₂O₄

Pricing & Availability

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287891-50MG
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      Description
      OverviewA potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.
      Catalogue Number287891
      Brand Family Calbiochem®
      Synonyms5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
      References
      ReferencesKim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
      Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
      Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
      Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
      Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
      Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
      Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
      Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.
      Product Information
      CAS number53-85-0
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₂H₁₂Cl₂N₂O₄
      Chemical formulaC₁₂H₁₂Cl₂N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcasein kinase II
      Primary Target IC<sub>50</sub>6 µM
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDD7310000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsRoom temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      287891-50MG 04055977197884

      Documentation

      5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      287891

      References

      Reference overview
      Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
      Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
      Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
      Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
      Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
      Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
      Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
      Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2009 RFH
      Synonyms5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
      DescriptionAccentuates premature termination of transcription close to the promoter. Useful for isolation of RNA sequences near promoter sites that are responsible for mRNA formation. Useful for reversible superinduction of human fibroblast cultures. Potent, ATP-competivie and specific inhibitor of casein kinase II (IC50 = 6 µM). Has been used to inhibit RNA polymerase II transcription, which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes.
      FormWhite solid
      CAS number53-85-0
      RTECSDD7310000
      Chemical formulaC₁₂H₁₂Cl₂N₂O₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (3 mg/ml) or Ethanol (3 mg/ml). May require warming (47°C) to achieve complete dissolution.
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsRoom temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
      Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
      Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
      Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
      Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
      Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
      Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
      Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.