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454180 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem

A natural metabolite of 17β-estradiol that is devoid of estrogenic activity.

2-Methoxyestradiol - CAS 362-07-2 - Calbiochem: Malzeme Güvenlik Bilgi Formu (MSDS) veya SDS, Analiz Sertifikası (COA) ve Kalite Uygunluk Sertifikası (COQ), dosyalar, broşürler ve diğer dokümanlar.

Synonyms: 2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene

Primary Target: Inhibits cell proliferation and angiogenesis
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454180
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
362-07-2C₁₉H₂₆O₃

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      454180-50MG
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          Description
          OverviewA natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits the neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
          Catalogue Number454180
          Brand Family Calbiochem®
          Synonyms2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
          References
          ReferencesAizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
          Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
          D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
          Forsis, T., et al. 1994. Nature 368, 237.
          Product Information
          CAS number362-07-2
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₁₉H₂₆O₃
          Chemical formulaC₁₉H₂₆O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetInhibits cell proliferation and angiogenesis
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25-36/37/38

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          454180-10MG 04055977204728
          454180-50MG 04055977204735

          Documentation

          2-Methoxyestradiol - CAS 362-07-2 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          2-Methoxyestradiol - CAS 362-07-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          454180

          References

          Reference overview
          Aizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
          Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
          D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
          Forsis, T., et al. 1994. Nature 368, 237.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          Synonyms2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
          DescriptionA natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin and has been suggested to function as a natural regulator of microtubule assembly and function.
          FormWhite crystalline solid
          CAS number362-07-2
          Chemical formulaC₁₉H₂₆O₃
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO or Ethanol
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Toxicity Toxic
          ReferencesAizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
          Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
          D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
          Forsis, T., et al. 1994. Nature 368, 237.