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681535
Sigma-AldrichWithaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
More>>A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Catalogue Number
681535
Brand Family
Calbiochem®
References
References
Mohan, R., et al. 2004. Angiogenesis7, 115. Jeyaprakasam, B., et al. 2003. Life Sci.74, 125. Devi, P.U., et al. 1995. Cancer Lett.95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858.
Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem Certificates of Analysis
Title
Lot Number
681535
References
Reference overview
Mohan, R., et al. 2004. Angiogenesis7, 115. Jeyaprakasam, B., et al. 2003. Life Sci.74, 125. Devi, P.U., et al. 1995. Cancer Lett.95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
16-September-2008 RFH
Description
A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
5119-48-2
RTECS
KE7288500
Chemical formula
C₂₈H₃₈O₆
Structure formula
Purity
≥94% by HPLC
Solubility
DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Carcinogenic / Teratogenic
References
Mohan, R., et al. 2004. Angiogenesis7, 115. Jeyaprakasam, B., et al. 2003. Life Sci.74, 125. Devi, P.U., et al. 1995. Cancer Lett.95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858.
