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647950 Triclosan - CAS 3380-34-5 - Calbiochem

A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase.

Triclosan - CAS 3380-34-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Chloro-2-(2,4-dichlorophenoxy)phenol

647950
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      3380-34-5C₁₂H₇Cl₃O₂
      Description
      OverviewA potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase. A slow-binding inhibitor that forms a stable ternary complex (bsFabl.NAD+.triclosan) in Bacillus subtilis.
      Catalogue Number647950
      Brand Family Calbiochem®
      Synonyms5-Chloro-2-(2,4-dichlorophenoxy)phenol
      References
      ReferencesMcLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
      Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
      Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
      Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
      Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
      Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
      McMurray, L.M., et al. 1998. Nature 394, 531.
      Product Information
      CAS number3380-34-5
      FormWhite powder or crystalline powder
      Hill FormulaC₁₂H₇Cl₃O₂
      Chemical formulaC₁₂H₇Cl₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKO1100000
      Safety Information
      R PhraseR: 36/37/38-50/53

      Irritating to eyes, respiratory system and skin.
      Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
      S PhraseS: 26-36/39-46-60-61

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing and eye/face protection.
      If swallowed, seek medical advice immediately and show this container or label.
      This material and its container must be disposed of as hazardous waste.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Environmental Hazard
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      647950 0

      Documentation

      Triclosan - CAS 3380-34-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Triclosan - CAS 3380-34-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      647950

      References

      Reference overview
      McLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
      Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
      Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
      Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
      Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
      Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
      McMurray, L.M., et al. 1998. Nature 394, 531.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-July-2019 JSW
      Synonyms5-Chloro-2-(2,4-dichlorophenoxy)phenol
      DescriptionA potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fab l encoded enoyl-acyl carrier protein (ACP) reductase. A slow binding inhibitor that forms a stable ternary complex (bsFabl.NAD+. triclosan) in Bacillus subtilis. Also inhibits the growth of Plasmodium falciparum by inhibiting the apicomplexan Fab I (IC50 = 154.4 ng/ml for W2 strain and 387 ng/ml for D6 strain).
      FormWhite powder or crystalline powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number3380-34-5
      RTECSKO1100000
      Chemical formulaC₁₂H₇Cl₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityAqueous NaOH
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Environmental Hazard
      ReferencesMcLeod, R., et al. 2001. Int. J. Parasitology 31, 109.
      Surolia, N. and Surolia, A., 2001. Nat. Medicine 7, 167.
      Heath, R.J., et al. 2000. J. Biol. Chem. 275, 4654.
      Heath, R.J., et al. 1999. J. Biol. Chem. 274, 11110.
      Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol. 181, 5489.
      Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
      McMurray, L.M., et al. 1998. Nature 394, 531.