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Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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533574
Sigma-AldrichTRPML3 Activator, ML123 - CAS 384352-24-3 - Calbiochem
A highly selective agonist of TRPML3 channel (EC₅₀ = 873 nM)
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Description
Overview
A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395. Grimm, C., et al. 2012. J. Biol. Chem.287, 22701. Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program. Grimm, C., et al. 2010. Chem. Biol.17, 135.
Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395. Grimm, C., et al. 2012. J. Biol. Chem.287, 22701. Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program. Grimm, C., et al. 2010. Chem. Biol.17, 135.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
384352-24-3
Chemical formula
C₁₆H₂₃ClN₂O₃S
Purity
≥92% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395. Grimm, C., et al. 2012. J. Biol. Chem.287, 22701. Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program. Grimm, C., et al. 2010. Chem. Biol.17, 135.
