Millipore Sigma Vibrant Logo

613560 TMPyP4 - CAS 36951-72-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
36951-72-1C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
613560-25MG
Limited Availability
Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 25 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.
      Catalogue Number613560
      Brand Family Calbiochem®
      Synonymsmeso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
      References
      ReferencesYamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
      Izbicka, E., et al. 1999. Cancer Res. 59, 639.
      Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
      Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
      Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.
      Product Information
      CAS number36951-72-1
      ATP CompetitiveN
      FormPurple solid
      Hill FormulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
      Chemical formulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targethuman telomerase
      Primary Target IC<sub>50</sub>6.5 µM inhibiting human telomerase
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      613560-25MG 04055977263541