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Buffer Detection Kit for Magnetic Beads
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613560
Sigma-AldrichTMPyP4 - CAS 36951-72-1 - Calbiochem
A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).
More>>A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). Less<<
TMPyP4 - CAS 36951-72-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.
Form
Purple solid
CAS number
36951-72-1
Chemical formula
C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
Structure formula
Purity
≥90% by TLC
Solubility
H₂O (1 mg/ml)
Storage
Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433. Izbicka, E., et al. 1999. Cancer Res. 59, 639. Anantha, N.V., et al. 1998. Biochemistry 37, 2709. Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724. Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.
