553210 Sigma-AldrichRapamycin - CAS 53123-88-9 - Calbiochem
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Synonyms: mTOR Inhibitor I
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 53123-88-9 | C₅₁H₇₉NO₁₃ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 553210-100UG |
|
Plastic ampoule | 100 μg |
|
— | |
| 553210-10MG |
|
Glass bottle | 10 mg |
|
— | |
| 553210-1MG |
|
Plastic ampoule | 1 mg |
|
— | |
| 553210-5MG |
|
Glass bottle | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available. |
| Catalogue Number | 553210 |
| Brand Family | Calbiochem® |
| Synonyms | mTOR Inhibitor I |
| Product Information | |
|---|---|
| CAS number | 53123-88-9 |
| ATP Competitive | N |
| Form | Clear film |
| Hill Formula | C₅₁H₇₉NO₁₃ |
| Chemical formula | C₅₁H₇₉NO₁₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ200 |
| Biological Information | |
|---|---|
| Primary Target | Mammalian target of rapamycin (mTOR) |
| Primary Target IC<sub>50</sub> | 50 pM against p70 S6 kinase |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Safety Information according to GHS | |
|---|---|
| RTECS | VE6250000 |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 553210-100UG | 04055977193510 |
| 553210-10MG | 07790788060305 |
| 553210-1MG | 04055977193480 |
| 553210-5MG | 04055977193534 |