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506154 Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole

Primary Target: p53
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506154
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
60477-38-5C₁₅H₁₃N₃O₂S

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      Description
      OverviewA cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).
      Catalogue Number506154
      Brand Family Calbiochem®
      Synonyms2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole
      References
      ReferencesPietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.
      Product Information
      CAS number60477-38-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₃N₃O₂S
      Chemical formulaC₁₅H₁₃N₃O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp53
      Primary Target IC<sub>50</sub>ED50 = 30 nM in protecting etoposide-induced cortical neuron death
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506154-5MG 04055977272246

      Documentation

      Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      506154

      References

      Reference overview
      Pietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.

      Brochure

      Title
      p53 And Related Products
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-March-2013 JSW
      Synonyms2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole
      DescriptionA cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number60477-38-5
      Chemical formulaC₁₅H₁₃N₃O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (2.5 mg/ml) or Ethanol (250 µg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.