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654271 MetAP2 Inhibitor, A832234 - Calbiochem

654271
  
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      Overview

      Key Spec Table

      Empirical Formula
      C₂₄H₂₉FN₂O₄S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable anthranilic acid sulfonamide compound that acts as a potent and reversible inhibitor of methionine aminopetidase-2 (MetAP2, IC50 = 11 nM). Acts by directly targeting the active site of MetAP2 without any significant binding to human serum albumin. Also shown to inhibit cellular MetAP2 activity (EC50 = 5.3 nM) and block the proliferation of HT1080 fibrosarcoma cells (EC50 = 6 nM).

      Catalogue Number654271
      Brand Family Calbiochem®
      SynonymsMethionine aminopeptidase-2 Inhibitor, 2-[({2-[(1Z)-3-(Diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic Acid, Methionyl aminopeptidase 2 Inhibitor
      References
      ReferencesSheppard, G. S., et al. 2006. J Med Chem. 49, 3832
      Product Information
      FormLight beige solid
      Hill FormulaC₂₄H₂₉FN₂O₄S
      ReversibleY
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetMetAP2
      Primary Target IC<sub>50</sub>11 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      654271 0