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504905
Sigma-AldrichMemantine Hydrochloride - CAS 41100-52-1 - Calbiochem
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.
More>>Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Catalogue Number
504905
Brand Family
Calbiochem®
Synonyms
3,5-Dimethyl-1-adamantanamine hydrochloride
References
References
Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255. Anand, A., et al. 2012. Bipolar Dis.14, 64. Lopes, P., et al. 2013. Brain and Behavior.3, 67. Howard, R., et al. 2012. New Eng. J. Med.366, 893. Parsons, G., et al. 1999. Neuropharmacol.38, 735. Lee, G., et al. 2012. Psychiatry Investig.9, 166.
Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255. Anand, A., et al. 2012. Bipolar Dis.14, 64. Lopes, P., et al. 2013. Brain and Behavior.3, 67. Howard, R., et al. 2012. New Eng. J. Med.366, 893. Parsons, G., et al. 1999. Neuropharmacol.38, 735. Lee, G., et al. 2012. Psychiatry Investig.9, 166.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
17-July-2013 JSW
Synonyms
3,5-Dimethyl-1-adamantanamine hydrochloride
Description
A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Form
White solid
CAS number
41100-52-1
Chemical formula
C₁₂H₂₁N•HCl
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (100 mM)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255. Anand, A., et al. 2012. Bipolar Dis.14, 64. Lopes, P., et al. 2013. Brain and Behavior.3, 67. Howard, R., et al. 2012. New Eng. J. Med.366, 893. Parsons, G., et al. 1999. Neuropharmacol.38, 735. Lee, G., et al. 2012. Psychiatry Investig.9, 166.