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504905 Memantine Hydrochloride - CAS 41100-52-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
41100-52-1C₁₂H₂₁N•HCl

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5.04905.0001
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      Glass bottle 50 mg
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      Description
      OverviewA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
      Catalogue Number504905
      Brand Family Calbiochem®
      Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
      References
      ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
      Anand, A., et al. 2012. Bipolar Dis. 14, 64.
      Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
      Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
      Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
      Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
      Product Information
      CAS number41100-52-1
      FormWhite solid
      Hill FormulaC₁₂H₂₁N•HCl
      Chemical formulaC₁₂H₂₁N•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      5.04905.0001 04055977263633