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444130 Mcl-1 Inhibitor, MIM1 - Calbiochem

Mcl-1 Inhibitor, MIM1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1

444130
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444130-25MG
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      Description
      OverviewA cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF.
      Catalogue Number444130
      Brand Family Calbiochem®
      Synonyms4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1
      References
      ReferencesCohen, N.A., et al. 2012. Chem. Biol. 19, 1175.
      Product Information
      FormYellow powder
      Hill FormulaC₁₇H₂₁N₃O₃S
      Chemical formulaC₁₇H₂₁N₃O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetMcl-1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      444130-25MG 04055977205428