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444283 MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
544678-85-5C₂₂H₂₀F₂N₄O₂

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444283-1MG
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      Description
      OverviewA pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
      Catalogue Number444283
      Brand Family Calbiochem®
      SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
      References
      ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.
      Product Information
      CAS number544678-85-5
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₂₂H₂₀F₂N₄O₂
      Chemical formulaC₂₂H₂₀F₂N₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetMMP-13 activity
      Primary Target IC<sub>50</sub>8 nM against MMP-13
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      444283-1MG 04055977186000