529605 Sigma-AldrichInSolution™ PP1 Analog - CAS 221243-82-9 - Calbiochem
A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src compared to wild-type v-Src.
More>> A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src compared to wild-type v-Src. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 221243-82-9 | C₁₉H₁₉N₅ |
| Description | |
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| Overview | A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1.0 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO. |
| Catalogue Number | 529605 |
| Brand Family | Calbiochem® |
| References | |
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| References | Bishop, A.C., et al. 2000. Nature 407, 395. Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627. |
| Product Information | |
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| CAS number | 221243-82-9 |
| Declaration | Not available for sale in the United States. |
| Form | Liquid |
| Formulation | A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO. |
| Hill Formula | C₁₉H₁₉N₅ |
| Chemical formula | C₁₉H₁₉N₅ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Dimensions |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 36/38 Irritating to eyes and skin. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 529605 | 0 |
Documentation
InSolution™ PP1 Analog - CAS 221243-82-9 - Calbiochem SDS
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InSolution™ PP1 Analog - CAS 221243-82-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 529605 |
References
| Reference overview |
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| Bishop, A.C., et al. 2000. Nature 407, 395. Bishop, A.C., et al. 1999 J. Am. Chem. Soc. 121, 627. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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