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401486 IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem

IKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IKK 16

Primary Target: IKK
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401486
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Overview

Key Spec Table

CAS #Empirical Formula
873225-46-8C₂₈H₂₉N₅OS

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401486-1MG
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      Description
      OverviewA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378).
      Catalogue Number401486
      Brand Family Calbiochem®
      SynonymsIKK 16
      References
      ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
      Product Information
      CAS number873225-46-8
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₂₈H₂₉N₅OS
      Chemical formulaC₂₈H₂₉N₅OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively).
      Biological Information
      Primary TargetIKK
      Primary Target IC<sub>50</sub>40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      401486-1MG 04055977212013