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382120 Histone Acetyltransferase Activator, CTB - CAS 451491-47-7 - Calbiochem

The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure ap

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Synonyms: N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator

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382120
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Overview

Key Spec Table

CAS #Empirical Formula
451491-47-7C₁₆H₁₃ClF₃NO₂

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382120-25MG
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      Description
      OverviewA benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.
      Catalogue Number382120
      Brand Family Calbiochem®
      SynonymsN-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
      References
      ReferencesMantelingu, K., et al. 2007. J. Phys. Chem. B 111, 4527.
      Product Information
      CAS number451491-47-7
      FormOff-white solid
      Hill FormulaC₁₆H₁₃ClF₃NO₂
      Chemical formulaC₁₆H₁₃ClF₃NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥90% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      382120-25MG 04055977213133