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345701
Sigma-AldrichGambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.
More>>A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).
Catalogue Number
345701
Brand Family
Calbiochem®
Synonyms
Guttic Acid, β-Guttiferin
References
References
Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084. Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769. Asano, J., et al. 1996. Phytochemistry41, 815.
MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells
Purity
≥95% by TLC
Physicochemical Information
Cell permeable
Y
Safety Information according to GHS
RTECS
PB9268200
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
Catalogue Number
GTIN
345701-25MG
04055977193787
Documentation
Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem SDS
Gambogic Acid, Garcinia hanburyi - CAS 2752-65-0 - Calbiochem Certificates of Analysis
Title
Lot Number
345701
References
Reference overview
Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084. Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769. Asano, J., et al. 1996. Phytochemistry41, 815.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
05-July-2017 JSW
Synonyms
Guttic Acid, β-Guttiferin
Description
A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.
Form
Amorphous orange solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
2752-65-0
RTECS
PB9268200
Chemical formula
C₃₈H₄₄O₈
Structure formula
Purity
≥95% by TLC
Solubility
DMSO (10 mg/ml) or Ethanol
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 4361
References
Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084. Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769. Asano, J., et al. 1996. Phytochemistry41, 815.
