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345810 G 418 Sulfate, Cell Culture Tested - CAS 108321-42-2 - Calbiochem

G418 also known as Geneticin® is an aminoglycoside antibiotic related to Gentamicin. Used as a selective agent in transfection of eukaryotic cells. Has highest potency ≥730 µg/mg and purity ≥98%.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NMD Inhibitor I, G418, G 418

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      Overview

      Key Spec Table

      CAS #Empirical Formula
      108321-42-2C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
      Description
      OverviewAminoglycoside related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
      Also available as a sterile-filtered aqueous solution (Cat. No. 345812), a sterile filtered solution in 100 mM HEPES (Cat. No. 508940), and a sterile-filtered solution PBS (Cat. No. 509227).
      Catalogue Number345810
      Brand Family Calbiochem®
      SynonymsNMD Inhibitor I, G418, G 418
      References
      ReferencesEthier, S.P., and Taback, E. 1993. Cancer Lett. 74, 189.
      Santerre, R.F., et al. 1991. Methods Mol. Biol. 7, 245.
      Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition, Cold Spring Harbor, NY.
      Edwards, S.A., and Adamson, E.D. 1987. J. Cell Physiol. 133, 46.
      Ernst, J.F., and Chan, R.K. 1985. J. Bacteriol. 163, 8.
      Canaani, D., and Berg, P. 1982. Proc. Natl. Acad. Sci. USA 79, 5166.
      Hirth, K.P., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 7356.
      Ursic, D., et al. 1981. Biochem. Biophys. Res. Commun. 101, 1031.
      Jimenez, A., and Davies, J. 1980. Nature 287, 869.
      Product Information
      CAS number108321-42-2
      FormWhite powder
      Hill FormulaC₂₀H₄₀N₄O₁₀ · 2H₂SO₄
      Chemical formulaC₂₀H₄₀N₄O₁₀ · 2H₂SO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Biological activityAssay: ≥730 µg/mg
      Purity≥98% by TLC
      Physicochemical Information
      ContaminantsAmmonia: ≤1.0%; heavy metals: ≤100 ppm
      Safety Information according to GHS
      RTECSCB9378500
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm or 0.45 µm pore size filter, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Sterile stock solutions are stable for up to 1 year at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      345810 0