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328000 ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem

The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications

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Synonyms: Ste-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV

Primary Target: MEK
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328000
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Overview

Key Spec Table

Empirical Formula
C₈₆H₁₅₃N₁₉O₁₇S

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328000-1MG
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      Description
      OverviewA cell-permeable and reversible stearated 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 2.5 µM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 13 µM). Does not affect the activation of JNKs or p38.
      Catalogue Number328000
      Brand Family Calbiochem®
      SynonymsSte-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV
      References
      ReferencesKelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₈₆H₁₅₃N₁₉O₁₇S
      Chemical formulaC₈₆H₁₅₃N₁₉O₁₇S
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetMEK
      Primary Target IC<sub>50</sub>2.5 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceSte-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      328000-1MG 04055977196337