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23-031M Cyclin E1 Protein complex, 250 µg

Complex of full length, recombinant human proteins Cyclin E1 & CDK2. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Key Applications: Enzyme Assays
23-031M
250 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman Substrate
      Description
      Catalogue Number23-031M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCyclin E1 Protein complex, 250 µg
      OverviewFlocked swab:
      Spray-on Nylon is the secret to flocked swab technology. The short, perpendicular fiber strands produced by the spray on method, creates an absorbent, thin-layer open structure that enhances both sample collection and release through the natural capillary movement of liquid along the fibers. Elution of the liquid and solid specimen sample is rapid and automatic because they are maintained close to the surface of the swab between the nylon strands, spontaneously draining when placed in liquid or onto solid media. Swab shafts are scored at a specific break-point for easy transfer of the tip into transportation media.
      Alternate Names
      • CDK2/CyclinE
      • CDK2/Cyclin E1
      Background InformationCyclin E1 functions as a regulator of the cell cycle, promoting the G1 to S phase transition by binding to and activating the cyclin dependent kinase CDK2. The abundance of cyclin E1 fluctuates during a normal cell cycle and is controlled at the level of gene transcription and by ubiquitin dependent proteolysis. Non-complexed cyclin E1 is degraded by the Cul3 pathway, however when cyclin E1 is bound to CDK2 its ubiqutination is dependent on a positive phosphorylation status, which enables its recognition by SCFFbw7. The impact of cyclin E1 quantities on cell cycle regulation is reflected in the elevated levels expressed by many types of human tumours.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationComplex of full length, recombinant human proteins Cyclin E1 & CDK2. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      23-031M 04053252294471

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      23-031 Cyclin E1 complex Show Pricing & Availability

      Product Families

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
      Learn More >>

      Categories

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates