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204884 Complement C3a des-Arg, Human

Complement C3a des-Arg, Human, is a single chain native des-Arg C3 complement component

Complement C3a des-Arg, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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204884
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Overview

Replacement Information

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204884-50UG
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      		 Plastic ampoule 50 μg
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      Description
      OverviewNative, human des-Arg C3 complement component. Single chain, 76 amino acid peptide. Once the C3a peptide has been produced in human plasma or serum, it is rapidly converted to C3a des-Arg upon removal of the C-terminal arginine by endogenous serum carboxypeptidase N. This enzymatic process is considered to be a major mechanism for controlling C3a function in vivo because C3a des-Arg has <1% of the biological activity expressed by the C3a peptide. Therefore, C3a des-Arg can serve as a negative control molecule in experiments involved with the biological activities of the intact C3a anaphylatoxin peptide.
      Catalogue Number204884
      Brand Family Calbiochem®
      References
      ReferencesKajita, T. and Hugli, T.E. 1991. Am. J. Pathol. 138, 1359.
      Bokish, V.A. and Muller-Eberhard, H.J. 1970. J. Clin. Invest. 49, 2427.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityIleum contraction assay: negative
      Purity≥90% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      204884-50UG 04055977219784

      Documentation

      Complement C3a des-Arg, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Complement C3a des-Arg, Human Certificates of Analysis

      TitleLot Number
      204884

      References

      Reference overview
      Kajita, T. and Hugli, T.E. 1991. Am. J. Pathol. 138, 1359.
      Bokish, V.A. and Muller-Eberhard, H.J. 1970. J. Clin. Invest. 49, 2427.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-December-2018 JSW
      DescriptionNative, human des-Arg C3 complement component. Single chain, 76 amino acid peptide. Once the C3a peptide has been produced in human plasma or serum, it is rapidly converted to C3a des-Arg upon removal of the C-terminal arginine by endogenous serum carboxypeptidase N. This enzymatic process is considered to be a major mechanism for controlling C3a function in vivo because C3a des-Arg has <1% of the biological activity expressed by the C3a peptide. Therefore, C3a des-Arg can serve as a negative control molecule in experiments involved with the biological activities of the intact C3a anaphylatoxin peptide.
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥90% by SDS-PAGE
      Biological activityIleum contraction assay: negative
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesKajita, T. and Hugli, T.E. 1991. Am. J. Pathol. 138, 1359.
      Bokish, V.A. and Muller-Eberhard, H.J. 1970. J. Clin. Invest. 49, 2427.