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219557 Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: sterol & fatty acid biosynthesis
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219557
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Overview

Key Spec Table

CAS #Empirical Formula
17397-89-6C₁₂H₁₇NO₃

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219557-5MG
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      Description
      OverviewAn antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.
      Catalogue Number219557
      Brand Family Calbiochem®
      References
      ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
      Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
      Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
      Product Information
      CAS number17397-89-6
      FormWhite to off-white solid
      Hill FormulaC₁₂H₁₇NO₃
      Chemical formulaC₁₂H₁₇NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetsterol & fatty acid biosynthesis
      Purity≥98% by TLC
      Safety Information according to GHS
      RTECSJR1670000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      219557-5MG 04055977218138