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217713 Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

The Cdk1/2 Inhibitor II, NU6102, also referenced under CAS 444722-95-6, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A3
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217713
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
444722-95-6C₁₈H₂₂N₆O₃S

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      Description
      OverviewA cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC50 = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI50 of 8 µM.
      Catalogue Number217713
      Brand Family Calbiochem®
      Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
      References
      ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
      Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
      Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
      Product Information
      CAS number444722-95-6
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₈H₂₂N₆O₃S
      Chemical formulaC₁₈H₂₂N₆O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B, Cdk2/cyclin A3
      Primary Target IC<sub>50</sub>9.5 nM, 5.4 nM against Cdk1/cyclin B, Cdk2/cyclin A3, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      217713-1MG 04055977202373

      Documentation

      Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      217713

      References

      Reference overview
      Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
      Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
      Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
      DescriptionA cell-permeable purine analog that displays anti-proliferative properties and acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM, respectively). Displays greater selectivity for Cdk's over other kinases tested (IC50 = 30 nM, 600 nM, 800 nM, 900 nM, and 1.6 µM for Cdk2/A, ROCKII, PDK1, DYRK1A, and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth (GI50 of 8 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number444722-95-6
      Chemical formulaC₁₈H₂₂N₆O₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
      Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
      Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.