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218828 Caspase-1 Substrate XV, Cell-Permeable, Fluorogenic

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nα-5-Tetramethylrhodaminyl-YVADAC(S-acrylodan)-OH, TMR-YVADAC(AD)

218828
  
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      Overview

      Description
      Overview

      This product has been discontinued.



      Please refer to our complete listing of caspase substrates for possible alternatives.






      A cell-permeable, internally-quenched fluorogenic peptide substrate that is useful for detecting in vivo caspase-1-like protease activity in living cells or tissues. Efficiently cleaved by caspase-1 in vitro at the peptide bond between Asp and Ala residues (kcat/Km ~ 8.5 x 10-2 µM-1s-1) with an increase in fluorescence intensity (~525 nm) when excited at 380 nm. Both time-dependent and sub-cellular localization of caspase-1-like activity could be visualized in glutamate-induced rat hippocampal cell death.
      Catalogue Number218828
      Brand Family Calbiochem®
      SynonymsNα-5-Tetramethylrhodaminyl-YVADAC(S-acrylodan)-OH, TMR-YVADAC(AD)
      References
      ReferencesNishii, W., et al. 2002. FEBS Lett. 518, 149.
      Product Information
      FormRed-purple lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₇H₇₅N₉O₁₅S
      Chemical formulaC₆₇H₇₅N₉O₁₅S
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Peptide SequenceTAMRA(5)-Tyr-Val-Ala-Asp-Ala-Cys(S-acrylodan)-OH
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      218828 0