Millipore Sigma Vibrant Logo

197331 Bcl-2 Inhibitor II, YC137 - CAS 810659-53-1 - Calbiochem

The Bcl-2 Inhibitor II, YC137, also referenced under CAS 810659-53-1, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester

Primary Target: Bcl-2
View Products on Sigmaaldrich.com
197331
View Pricing & Availability

Overview

Key Spec Table

CAS #Empirical Formula
810659-53-1C₂₄H₂₁N₃O₆S₂

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
197331-5MG
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 5 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewA cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells, and Bcl-xL-dependent cells, even at a concentration of 5 µM. Preferentially binds Bcl-2 (Ki = 1.3 µM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. Shown to induce the release of cytochrome c from mitochondria and activate caspase-9.
      Catalogue Number197331
      Brand Family Calbiochem®
      Synonyms2-Methoxycarbonylamino-4-methylsulfanyl-butyric acid, 4-(4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-ylamino)-phenyl ester
      References
      ReferencesReal, P.J., et al. 2004. Cancer Res. 64, 7947.
      Product Information
      CAS number810659-53-1
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₄H₂₁N₃O₆S₂
      Chemical formulaC₂₄H₂₁N₃O₆S₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetBcl-2
      Primary Target K<sub>i</sub>1.3 µM in binding Bcl-2
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      197331-5MG 04055977206081