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Buffer Detection Kit for Magnetic Beads
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196805
Sigma-AldrichBax Channel Blocker - CAS 335165-69-0 - Calbiochem
A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.
More>>A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
Bax Channel Blocker - CAS 335165-69-0 - Calbiochem Certificates of Analysis
Title
Lot Number
196805
References
Reference overview
Peixoto, P., et al. 2009. Biochem J.423, 381. Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.
Form
Off-white solid
Formulation
Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)
Packaged under inert gas
CAS number
335165-69-0
Chemical formula
C₁₉H₂₁Br₂N₃O
Purity
≥95% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Carcinogenic / Teratogenic
References
Peixoto, P., et al. 2009. Biochem J.423, 381. Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.
