Millipore Sigma Vibrant Logo

178494 Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
426834-38-0C₁₅H₁₀ClF₃N₂O₃

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
178494-10MG
Limited Availability
Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 10 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
      Catalogue Number178494
      Brand Family Calbiochem®
      SynonymsNS3694
      References
      ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
      Product Information
      CAS number426834-38-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₀ClF₃N₂O₃
      Chemical formulaC₁₅H₁₀ClF₃N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetApoptosome complex formation
      Primary Target IC<sub>50</sub>50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      178494-10MG 04055977204803