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PC373 Anti-p40 (5-17) Rabbit pAb

This Anti-p40 (5-17) Rabbit pAb is validated for use in Immunoblotting, Paraffin Sections for the detection of p40 (5-17).

Anti-p40 (5-17) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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PC373
  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      HRbPolyclonal Antibody
      Description
      OverviewRecognizes the ~40 kDa p40 protein in SKOV3 cells and breast carcinoma tissue.
      Catalogue NumberPC373
      Brand Family Calbiochem®
      Application Data
      Detection of human p40 by staining paraffin sections. Sample: Human breast carcinoma. Primary antibody: Anti-p40 (5-17) Rabbit pAb (Cat. No. PC373) (1:3000). Detection: DAB with methyl green counterstain.
      References
      ReferencesHibi, K., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 5462.
      Yamaguchi, K., et al. 2000. Int. J. Cancer 86, 684.
      Hagiwara, K.,et al. 1999. Cancer Res. 59, 4165.
      Kaelin W. G. Jr. 1999. J. Natl. Cancer Inst. 91, 594.
      Osada, M., et al. 1998. Nat. Med. 7, 839.
      Senoo, M., et al. 1998. Biochem. Biophys. Res. Commun. 248, 603.
      Trink, B., et al. 1998. Nat. Med. 4, 747.
      Yang, A., et al. 1998. Mol. Cell 2, 305.
      Product Information
      FormLiquid
      FormulationUndiluted serum.
      Positive controlSKOV3 cells or breast carcinoma tissue
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Immunoblotting (Western Blotting)
      Not Immunofluorescence
      Paraffin Sections
      Application NotesImmunoblotting (1:500, chemiluminescence)
      Paraffin Sections (1:3000, heat pre-treatment required)
      Application CommentsAntibody should be titrated for optimal results in individual systems.
      Biological Information
      Immunogena synthetic peptide corresponding to amino acids 5-17 of human p40
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      PC373 0

      Documentation

      Anti-p40 (5-17) Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-p40 (5-17) Rabbit pAb Certificates of Analysis

      TitleLot Number
      PC373

      References

      Reference overview
      Hibi, K., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 5462.
      Yamaguchi, K., et al. 2000. Int. J. Cancer 86, 684.
      Hagiwara, K.,et al. 1999. Cancer Res. 59, 4165.
      Kaelin W. G. Jr. 1999. J. Natl. Cancer Inst. 91, 594.
      Osada, M., et al. 1998. Nat. Med. 7, 839.
      Senoo, M., et al. 1998. Biochem. Biophys. Res. Commun. 248, 603.
      Trink, B., et al. 1998. Nat. Med. 4, 747.
      Yang, A., et al. 1998. Mol. Cell 2, 305.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-October-2007 RFH
      ApplicationImmunoblotting (1:500, chemiluminescence)
      Paraffin Sections (1:3000, heat pre-treatment required)
      Application Data
      Detection of human p40 by staining paraffin sections. Sample: Human breast carcinoma. Primary antibody: Anti-p40 (5-17) Rabbit pAb (Cat. No. PC373) (1:3000). Detection: DAB with methyl green counterstain.
      DescriptionRabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~40 kDa p40 protein.
      BackgroundAmong the more recently identified p53 homologues are p73 and p40/p63/p73L/p51/CUSP/KET. Existing as two splice variants with molecular weights of ~51 kDa and ~72 kDa, the p40 gene product is essential for normal epithelial development. The gene maps to the distal arm of chromosome 3q and is mutated in a diverse number of human cancers. The p40 gene is expressed in skeletal muscle, placenta, mammary gland, prostate, trachea, thymus, salivary gland, uterus, heart and lung. The p40 protein has the ability to transactivate many p53 reporter genes and also has the ability to induce apoptosis.
      HostRabbit
      Immunogen speciesHuman
      Immunogena synthetic peptide corresponding to amino acids 5-17 of human p40
      IsotypeIgG
      Specieshuman, not mouse
      Positive controlSKOV3 cells or breast carcinoma tissue
      FormLiquid
      FormulationUndiluted serum.
      PreservativeNone
      CommentsAntibody should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesHibi, K., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 5462.
      Yamaguchi, K., et al. 2000. Int. J. Cancer 86, 684.
      Hagiwara, K.,et al. 1999. Cancer Res. 59, 4165.
      Kaelin W. G. Jr. 1999. J. Natl. Cancer Inst. 91, 594.
      Osada, M., et al. 1998. Nat. Med. 7, 839.
      Senoo, M., et al. 1998. Biochem. Biophys. Res. Commun. 248, 603.
      Trink, B., et al. 1998. Nat. Med. 4, 747.
      Yang, A., et al. 1998. Mol. Cell 2, 305.