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MABT1568-100UG Anti-QSOX1 Antibody, clone MAb492.1

Anti-QSOX1, clone MAb492.1, Cat. No. MABT1568, is a mouse monoclonal antibody that detects QSOX1 and is tested for use in Immunocytochemistry, Immunofluorescence, and Inhibition Assay.

NewMABT1568-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABT1568-100UG
      DescriptionAnti-QSOX1 Antibody, clone MAb492.1
      Alternate Names
      • Sulfhydryl oxidase 1
      • EC number EC:1.8.3.2
      • hQSOX
      • Quiescin Q6
      Background InformationSulfhydryl oxidase 1 (UniProt: O00391; also known as EC number EC:1.8.3.2, hQSOX, Quiescin Q6) is encoded by the QSOX1 (also known as QSCN6, UNQ2520/PRO6013) gene (Gene ID: 5768) in human. QSOX1 is a single-pass membrane glycoprotein that is expressed is observed in heart, placenta, lung, liver, skeletal muscle, pancreas. It is synthesized with a signal peptide (aa 1-29), which is subsequently cleaved off to produce the mature protein. Its thioredoxin domain is localized in amino acids 36-156. Two main redox-active domains of QSOX1 have been described. The amino terminus interacts with the thiol-containing substrates and the carboxy terminus catalyzes reduction of molecular oxygen. It oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide. It introduces disulfide bonds into proteins with a high efficiency and prefers protein substrates rather than small mono- and di-thiol containing molecules. It is shown to be essential for proper assembly of extracellular matrix (ECM). Its higher expression is observed in several malignancies, especially breast and pancreatic carcinoma and it is a key enzyme involved in a tumor's ability to modify the ECM that enables tumors to communicate with and/or modify its environment at the tumor-stroma interface, resulting in invasion and subsequent growth of the tumor. Two isoforms of QSOX1 have been described that are produced by alternative splicing. (Ref.: Lake, DF., and Faigel, DO. (2014). Antioxid. Redox Signal. 21(3); 485-496; Grossman, I., et al. (2012). J. Mol. Biol. 425(22); 4366-4378).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS without preservatives.
      Quality LevelMQ200
      Applications
      ApplicationAnti-QSOX1, clone MAb492.1, Cat. No. MABT1568, is a mouse monoclonal antibody that detects QSOX1 and is tested for use in Immunocytochemistry, Immunofluorescence, and Inhibition Assay.
      Key Applications
      • Immunocytochemistry
      • Inhibition
      • Immunofluorescence
      Application NotesTested Applications

      Immunocytochemistry Analysis: A representative lot detected QSOX1 in Immunocytochemistry applications (Ilani, T., et al. (2013). Science. 341(6141):74-6).

      Immunofluorescence Analysis: A representative lot detected QSOX1 in Immunofluorescence applications (Ilani, T., et al. (2013). Science. 341(6141):74-6).

      Inhibition Assay: A representative lot modulated ECM properties and inhibited tumor cell migration. (Ilani, T., et al. (2013). Science.;341(6141):74-6; Feldman, T., et al. (2020). Oncotarget. 11(4):386-398).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenA recombinant fragment corresponding to 517 amino acids of human QSOX1 protein.
      CloneMAb492.1
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone MAb492.1 is a mouse monoclonal antibody that detects Sulfhydryl oxidase 1 (QSOX1).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • QSOX1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight82.58 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in MDA-MB-231 cells.

      Immunocytochemistry Analysis: A 1:1,000 dilution of this antibody detected QSOX1 in MDA-MB-231 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT1568-100UG 04065270937988