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MABE439 Anti-GATA6 Antibody, clone 1G2.2

MABE439
100 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE439
      DescriptionAnti-GATA6 Antibody, clone 1G2.2
      Alternate Names
      • GATA6
      • Transcription factor GATA-6
      • GATA-binding factor 6
      Background InformationGATA-6 is a developmental transcriptional activator important in terminal differentiation and proliferation of cells destined to be associated with the heart, gut and gut related tissues and organs. GATA-6 works in concert with SEMA3C and PLXNA2 transcription factors and regulates the expression of their target genes. GATA-6 is particularly important in heart development as a number of genetic mutations within GATA-6 give rise to defective syndromes involving the heart or the vessels of the heart. Interestingly, recent research into pulmonary hypertension disease in adults points to a critical role of GATA-6 expression in endothelial cells lining the blood vessels. Healthy blood vessels express GATA-6 very strongly but expression is lost during vascular injury and markedly down regulated in the endothelial cells found in diseased vessels. Because GATA-6 is a direct transcriptional regulator or important vascular proteins such as endothelin-1 receptor, endothelial nitric oxide synthase, and cytokines such as Fractalkine, GATA-6’s role in modulating the effects of pulmonary hypertension and other vascular syndromes is a subject of much research.
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-GATA6 Antibody, clone 1G2.2 is an antibody against GATA6 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:1,000 dilution from a representative lot detected GATA6 in 10 µg of human brain, human heart, human lung, human liver, human kidney, human skin, human spleen, human thymus, human pancreas, human ovary, human testis, human small intestine, human parathyroid, and human adrenal tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human GATA6.
      Clone1G2.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GATA6
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      Molecular Weight~70 and 40 kDa observed. The calculated molecular weight is 60 kDa, however GATA6 has been shown as a ~70 and ~40 kDa band in some western blots (Van Berlo, J.H., et al. (2010). Cir. Res. 107:1032-1040). Uncharacterized band(s) may appear in some lysates.
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human adrenal, human pancreas, human small intestinetissue, and human heart tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected GATA6 in 10 µg of human adrenal, human pancreas, human small intestinetissue, and human heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      MABE439 04055977136395