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172060 Andrographolide - CAS 5508-58-7 - Calbiochem

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

Andrographolide - CAS 5508-58-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Andro

Primary Target: NF-κB and AP-1 activation
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172060
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Overview

Key Spec Table

CAS #Empirical Formula
5508-58-7C₂₀H₃₀O₅

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172060-50MG
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      Description
      OverviewA bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
      Catalogue Number172060
      Brand Family Calbiochem®
      SynonymsAndro
      References
      ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
      Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
      Yu, B.C., et al. 2003. Planta Med. 69, 1075.
      Product Information
      CAS number5508-58-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₃₀O₅
      Chemical formulaC₂₀H₃₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetNF-κB and AP-1 activation
      Primary Target IC<sub>50</sub>≤ 15 µM against NF-κB and AP-1 activation
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSLU3490750
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      172060-50MG 04055977222883