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504377 AMPK Signaling Activator XIII, ZLN005 - CAS 4529-96-8 - Calbiochem

Calbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV

Primary Target: increases cellular ADP/ATP ratio via mitochondria respiration uncoupling
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504377
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Overview

Key Spec Table

CAS #Empirical Formula
4529-96-8C₁₇H₁₈N₂

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      		 Glass bottle 25 mg
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      Description
      OverviewA cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10 nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1α in muscle, but not liver, cell types both in cultures (5-20 µM in rat L6 myotubes) in vitro and in db/db mice (15 mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake.
      Catalogue Number504377
      Brand Family Calbiochem®
      Synonyms2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV
      References
      ReferencesZhang, L.N., et al. 2013. Diabetes. 62, 1297.
      Product Information
      CAS number4529-96-8
      FormPinkish-white powder
      Hill FormulaC₁₇H₁₈N₂
      Chemical formulaC₁₇H₁₈N₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalbiochem AMPK Activator, CAS 4529-96-8, inhibits luciferase activity, and activates AMPK signaling.
      Biological Information
      Primary Targetincreases cellular ADP/ATP ratio via mitochondria respiration uncoupling
      Secondary targetluciferase activity inhibitor
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.04377.0001 04055977264043