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565763 γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem

The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide

Primary Target: Aβ₄₂ production
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565763
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
287196-57-0C₁₆H₂₂FNO₂S

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      Description
      OverviewCell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
      Catalogue Number565763
      Brand Family Calbiochem®
      Synonyms1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
      References
      ReferencesRishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.
      Product Information
      CAS number287196-57-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₂FNO₂S
      Chemical formulaC₁₆H₂₂FNO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAβ₄₂ production
      Primary Target IC<sub>50</sub>1.8 µM against Aβ42 production
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565763-5MG 04055977267723

      Documentation

      γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      565763

      References

      Reference overview
      Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
      DescriptionA potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ42 (IC50 = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APPSα, but no change in secreted APPSβ, indicating a specific inhibition of γ-secretase activity.
      FormWhite solid
      CAS number287196-57-0
      Chemical formulaC₁₆H₂₂FNO₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.