Unlike most existing preclinical model
systems, SCC462 retains the capacity for spontaneous metastasis to the brain, the lungs, and other organs in immunocompetent mice following orthotopical inoculation by subdermal injection. SCC462 has been demononstrated to recapitulate the multi-stage process involving the interactions of disseminated metastatic
cells with the brain microenvironment, including instigation of astrogliosis, neuroinflammation, and vascular hyperpermeability.
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