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506158 p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

The p38 MAP Kinase Inhibitor VII, SD-169, also referenced under CAS 1670-87-7, controls the biological activity of p38 MAP Kinase.

p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Indole-5-carboxamide

506158
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1670-87-7C₉H₈N₂O

Products

Catalogue NumberPackaging Qty/Pack
506158-10MG Plastová ampulka 10 mg
Description
OverviewA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
Catalogue Number506158
Brand Family Calbiochem®
SynonymsIndole-5-carboxamide
References
ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
Product Information
CAS number1670-87-7
FormOff-white solid
Hill FormulaC₉H₈N₂O
Chemical formulaC₉H₈N₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506158-10MG 04055977272284

Documentation

p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem Certificates of Analysis

TitleLot Number
506158

References

Reference overview
Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-March-2009 RFH
SynonymsIndole-5-carboxamide
DescriptionA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1670-87-7
Chemical formulaC₉H₈N₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or H2O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.