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203695 bpV(phen) - CAS 42494-73-5 - Calbiochem

bpV(phen, CAS 42494-73-5, is an insulin mimetic and an inhibitor of protein phosphotyrosine phosphatase. More potent in dephosphorylating of autophosphorylated insulin receptor than orthovanadate.

bpV(phen) - CAS 42494-73-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII

Primary Target: PTEN
203695
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
42494-73-5K[VO(O₂)₂C₁₂H₈N₂]

Products

Catalogue NumberPackaging Qty/Pack
203695-10MG Plastová ampulka 10 mg
Description
OverviewA potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM).
The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
Catalogue Number203695
Brand Family Calbiochem®
SynonymsPotassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
References
ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
Drake, P.G., et al. 1996. Endocrinology 137, 4960.
Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
Yale, J.F., et al. 1995. Diabetes 44, 1274.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Product Information
CAS number42494-73-5
ATP CompetitiveN
FormYellow solid
Hill FormulaK[VO(O₂)₂C₁₂H₈N₂]
Chemical formulaK[VO(O₂)₂C₁₂H₈N₂]
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationbpV(phen, CAS 42494-73-5, is an insulin mimetic and an inhibitor of protein phosphotyrosine phosphatase. More potent in dephosphorylating of autophosphorylated insulin receptor than orthovanadate.
Biological Information
Primary TargetPTEN
Primary Target IC<sub>50</sub>38 nM
Purity≥99% by ⁵¹V-NMR
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203695-10MG 07790788048365

Documentation

bpV(phen) - CAS 42494-73-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

bpV(phen) - CAS 42494-73-5 - Calbiochem Certificates of Analysis

TitleLot Number
203695

References

Reference overview
Schmid, A.C., et al. 2004. FEBS Lett. 566, 35.
Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
Drake, P.G., et al. 1996. Endocrinology 137, 4960.
Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
Yale, J.F., et al. 1995. Diabetes 44, 1274.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Brochure

Title
Protein Phosphatases Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2012 JSW
SynonymsPotassium Bisperoxo(1,10-phenanthroline)oxovanadate (V), PTEN Inhibitor I, PTP Inhibitor VIII
DescriptionA potent insulin receptor kinase (IRK) activator and protein phosphotyrosine phosphatase inhibitor. Excellent insulin mimetic for in vitro and in vivo use (15 µg/kg). Inhibits in situ dephosphorylation of autophosphorylated insulin receptors with greater than 1000-fold potency over sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM). The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number42494-73-5
Chemical formulaK[VO(O₂)₂C₁₂H₈N₂]
Structure formulaStructure formula
Purity≥99% by ⁵¹V-NMR
SolubilityH₂O (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421.
Drake, P.G., et al. 1996. Endocrinology 137, 4960.
Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60.
Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784.
Yale, J.F., et al. 1995. Diabetes 44, 1274.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.