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681674 Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications

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Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI

681674
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Overview

Key Spec Table

CAS #Empirical Formula
305372-78-5C₂₁H₁₈ClN₃

Products

Catalogue NumberPackaging Qty/Pack
681674-5MG Sklená flaša 5 mg
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Description
OverviewA cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
Catalogue Number681674
Brand Family Calbiochem®
SynonymsCCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
References
ReferencesEwan, K., et al. 2010. Cancer Res. 70, 5963.
Product Information
CAS number305372-78-5
FormOff-white solid
Hill FormulaC₂₁H₁₈ClN₃
Chemical formulaC₂₁H₁₈ClN₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by 1H NMR
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
681674-5MG 04055977225228