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681637 Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III

Primary Target: Wee1 and Chk1
681637
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1177150-89-8C₂₀H₁₂N₂O₃ • H₂O
Description
Overview

This product has been discontinued.



A pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 >50 µM).
Catalogue Number681637
Brand Family Calbiochem®
Synonyms4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III
References
ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Squire, C.J., et al. 2005. Structure 13, 541.
Product Information
CAS number1177150-89-8
ATP CompetitiveY
FormOrange solid
Hill FormulaC₂₀H₁₂N₂O₃ • H₂O
Chemical formulaC₂₀H₁₂N₂O₃ • H₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetWee1 and Chk1
Primary Target IC<sub>50</sub>97 nM and 47 nM against Wee1 and Chk1, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
681637 0

Documentation

Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem Certificates of Analysis

TitleLot Number
681637

References

Reference overview
Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Squire, C.J., et al. 2005. Structure 13, 541.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III
DescriptionA pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 > 50µM).
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1177150-89-8
Chemical formulaC₂₀H₁₂N₂O₃ • H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or Ethanol (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
Squire, C.J., et al. 2005. Structure 13, 541.