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676480 VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem

VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII

Primary Target: (RTK) inhibitor
676480
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
15966-93-5C₁₈H₁₈N₂O₃
Description
Overview

This product has been discontinued.



A highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 µM).
Catalogue Number676480
Brand Family Calbiochem®
Synonyms(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII
References
ReferencesSun, L., et al. 1998. J. Med. Chem. 41, 2588.
Product Information
CAS number15966-93-5
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₈H₁₈N₂O₃
Chemical formulaC₁₈H₁₈N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target(RTK) inhibitor
Primary Target IC<sub>50</sub>70 nM against receptor tyrosine kinase (RTK)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676480 0

Documentation

VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem Certificates of Analysis

TitleLot Number
676480

References

Reference overview
Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-January-2010 RFH
Synonyms(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII
DescriptionA highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nm) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. It does not inhibit PDGFR, EGFR, and IGF-1 tyrosine kinase activities (IC50 >100 µm).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number15966-93-5
Chemical formulaC₁₈H₁₈N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSun, L., et al. 1998. J. Med. Chem. 41, 2588.