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676482 VEGFR Tyrosine Kinase Inhibitor III, KRN633

VEGFR Tyrosine Kinase Inhibitor III, KRN633 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: VEGF Receptor Tyrosine Kinase Inhibitor III, N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-Nʹ-propylurea, VEGFR2 Kinase Inhibitor XVIII, VEGFR1 Kinase Inhibitor IV, VEGFR3 Kinase Inhibitor III

676482
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.

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A cell-permeable, reversible, ATP-competitive inhibitor of VEGFR kinase activity (IC50 = 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). Inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 µM and 4.33 µM, respectively) and is inactive towards a panel of 17 other kinases (IC50 ≥ 10 µM). Shown to suppress VEGF-dependent, but not FGF-dependent, cellular signaling and cell proliferation. Although not cytotoxic to cancer cells, KRN633 exhibits excellent in vivo antitumor activity due to its inhibitory effects on vessel formation and vascular permeability.
Catalogue Number676482
Brand Family Calbiochem®
SynonymsVEGF Receptor Tyrosine Kinase Inhibitor III, N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-Nʹ-propylurea, VEGFR2 Kinase Inhibitor XVIII, VEGFR1 Kinase Inhibitor IV, VEGFR3 Kinase Inhibitor III
References
ReferencesNakamura, K., et al. 2004. Mol. Cancer Ther. 3, 1639.
Product Information
CAS number286370-15-8
FormWhite solid
Hill FormulaC₂₀H₂₁ClN₄O₄
Chemical formulaC₂₀H₂₁ClN₄O₄
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676482 0

Documentation

VEGFR Tyrosine Kinase Inhibitor III, KRN633 Certificates of Analysis

TitleLot Number
676482

References

Reference overview
Nakamura, K., et al. 2004. Mol. Cancer Ther. 3, 1639.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-September-2007 JSW
SynonymsVEGF Receptor Tyrosine Kinase Inhibitor III, N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-Nʹ-propylurea, VEGFR2 Kinase Inhibitor XVIII, VEGFR1 Kinase Inhibitor IV, VEGFR3 Kinase Inhibitor III
DescriptionA cell-permeable, reversible, ATP-competitive inhibitor of VEGFR kinase activity (IC50 = 170 nM, 160 nM, and 125 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively). Inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 µM and 4.33 µM, respectively) and is inactive towards a panel of 17 other kinases (IC50 ≥ 10 µM). Shown to suppress VEGF-dependent, but not FGF-dependent, cellular signaling and cell proliferation. Although not cytotoxic to cancer cells, KRN633 exhibits excellent in vivo antitumor activity due to its inhibitory effects on vessel formation and vascular permeability.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number286370-15-8
Chemical formulaC₂₀H₂₁ClN₄O₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesNakamura, K., et al. 2004. Mol. Cancer Ther. 3, 1639.