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676499 VEGFR 2/3 Kinase Inhibitor

VEGFR 2/3 Kinase Inhibitor MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione, Vascular Endothelial Growth Factor Receptor 2/3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXII, VEGFR2 Kinase Inhibitor XIX, VEGFR3 Kinase Inhibitor IV

676499
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.

Please refer to our complete listing of receptor tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A cell-permeable 2,3-diarylmaleimide compound that acts as a potent and ATP-competitive inhibitor of VEGFR-2 and -3 (IC50 = 2.5 nM and 5 nM, respectively) with >100-fold selectivity over 25 other commonly studied kinases. Exhibits excellent in vivo anti-angiogenic efficacy in chick embryo assay (81.7% inhibition of vessel area at the vasculosa site with agarose pellets containing 150 µg inhibitor).
Catalogue Number676499
Brand Family Calbiochem®
Synonyms3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione, Vascular Endothelial Growth Factor Receptor 2/3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXII, VEGFR2 Kinase Inhibitor XIX, VEGFR3 Kinase Inhibitor IV
References
ReferencesPeifer, C., et al. 2006. J. Med. Chem. 49, 7549. Peifer, C., et al. 2006. J. Med. Chem. 49, 1271.
Product Information
FormYellowish orange solid
Hill FormulaC₂₁H₁₈N₂O₅
Chemical formulaC₂₁H₁₈N₂O₅
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
676499 0

Documentation

VEGFR 2/3 Kinase Inhibitor Certificates of Analysis

TitleLot Number
676499

References

Reference overview
Peifer, C., et al. 2006. J. Med. Chem. 49, 7549. Peifer, C., et al. 2006. J. Med. Chem. 49, 1271.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-August-2007 RFH
Synonyms3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1H-pyrrole-2,5-dione, Vascular Endothelial Growth Factor Receptor 2/3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XXII, VEGFR2 Kinase Inhibitor XIX, VEGFR3 Kinase Inhibitor IV
DescriptionA cell-permeable 2,3-diarylmaleimide compound that acts as a potent and ATP-competitive inhibitor of VEGFR-2 and -3 (IC50 = 2.5 nM and 5 nM, respectively) with >100-fold selectivity over 25 other commonly studied kinases. Exhibits excellent in vivo anti-angiogenic efficacy in chick embryo assay (81.7% inhibition of vessel area at the vasculosa site with agarose pellets containing 150 µg inhibitor).
FormYellowish orange solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₁₈N₂O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (300 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesPeifer, C., et al. 2006. J. Med. Chem. 49, 7549. Peifer, C., et al. 2006. J. Med. Chem. 49, 1271.