539644 Sigma-AldrichUCN-01
A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.
More>> A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases. Less<<Synonyms: 7-Hydroxystaurosporine, Staurosporine, 7β-Hydroxy, Streptomyces sp., Chk1 Inhibitor VI, Chk2 Inhibitor V
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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112953-11-4 | C₂₈H₂₆N₄O₄ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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539644-500UG | Plastová ampulka | 500 μg |
Description | |
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Overview | A cell-permeable Staurosporine (Cat. No. 569397) derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases (IC50 = 29 nM, 34 nM, 30 nM, 590 nM and 530 nM for PKCα, PKCβ, PKCγ, PKCδ and PKCε; IC50 = 7 nM, 27 nM, 50 nM, 50 nM, 150 nM and 1.04 µM for Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2; IC50 = 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 µM for PDK1, lck, MAPKAP kinase-2, Akt, GSK-3β and PKA, respectively). At higher concentrations (> 15 µM), affects the activities of Src, PIM-1, CKII, DNA-PK, ErK1, ILK-1 and MAPKK1). Reported to suppress thymidylate synthase expression, induce apoptosis with caspase activation, and sensitize tumor cells to a range of DNA-damaging agents. |
Catalogue Number | 539644 |
Brand Family | Calbiochem® |
Synonyms | 7-Hydroxystaurosporine, Staurosporine, 7β-Hydroxy, Streptomyces sp., Chk1 Inhibitor VI, Chk2 Inhibitor V |
Product Information | |
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CAS number | 112953-11-4 |
ATP Competitive | Y |
Form | White to beige solid |
Hill Formula | C₂₈H₂₆N₄O₄ |
Chemical formula | C₂₈H₂₆N₄O₄ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
539644-500UG | 04055977194821 |
Documentation
UCN-01 MSDS
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UCN-01 Certificates of Analysis
Title | Lot Number |
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539644 |
References
Reference overview |
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Reinhardt, H.C., et al. 2007. Cancer Cell 11, 175. Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221. Sato, S., et al. 2002. Oncogene 21, 1727. Patel, V., et al. 2002. Clin. Cancer Res. 8, 3549. Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251. Busby, E.C., et al. 2000. Cancer Res. 60, 2108. Hsueh, C.T., et al. 1998. Clin. Cancer Res. 4, 2201. Akiyama, T., et al. 1997. Cancer Res. 57, 1495. Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207. Takahashi, I., et al. 1987, J. Antibiot. 40, 1782. |
Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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