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610225 Tigecycline - CAS 220620-09-7 - Calbiochem

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria.

Tigecycline - CAS 220620-09-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-t-Butylglycylamido-minocycline

610225
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
220620-09-7C₂₉H₃₉N₅O₈
Description
OverviewA broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD50 ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.
Catalogue Number610225
Brand Family Calbiochem®
Synonyms9-t-Butylglycylamido-minocycline
References
ReferencesSkrtic, M., et al. 2011. Cancer Cell 20, 674.
Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156.
Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518.
Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611.
Product Information
CAS number220620-09-7
FormOrange powder
Hill FormulaC₂₉H₃₉N₅O₈
Chemical formulaC₂₉H₃₉N₅O₈
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36-60-61

Irritating to eyes.
May impair fertility.
May cause harm to the unborn child.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
610225 0

Documentation

Tigecycline - CAS 220620-09-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Tigecycline - CAS 220620-09-7 - Calbiochem Certificates of Analysis

TitleLot Number
610225

References

Reference overview
Skrtic, M., et al. 2011. Cancer Cell 20, 674.
Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156.
Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518.
Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-July-2012 JSW
Synonyms9-t-Butylglycylamido-minocycline
DescriptionA broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD50 ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.
FormOrange powder
Intert gas (Yes/No) Packaged under inert gas
CAS number220620-09-7
Chemical formulaC₂₉H₃₉N₅O₈
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesSkrtic, M., et al. 2011. Cancer Cell 20, 674.
Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156.
Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518.
Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611.