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605195 Thrombin, Human Plasma, High Activity

Thrombin, Human Plasma, High Activity MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
605195
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
605195-1000U Plastová ampulka 1000 u
605195-100U Sklená flaša 100 u
605195-5000U Plastová ampulka 5000 u
Description
OverviewDesigned for use in thrombin clotting time tests. Key enzyme that activates factor XIII and converts fibrinogen into fibrin.
Catalogue Number605195
Brand Family Calbiochem®
References
ReferencesForsberg, G., et al. 1992. J. Protein Chem. 11, 201.
Garcia, J.G. 1992. J. Lab. Clin. Med. 120, 513.
Scarborough, R.M., et al. 1992. J. Biol. Chem. 267, 13146.
Weigel, L.M., et al. 1992. Infect. Immun. 60, 1568.
Product Information
CAS number9002-04-4
Unit of DefinitionOne unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.
FormLyophilized solid
FormulationLyophilized from 200 mM NaCl, 50 mM sodium citrate, 0.1% PEG-8000, pH 6.5.
Quality LevelMQ100
Applications
Biological Information
PurityComplete activation from homogeneous prothrombin by SDS-PAGE
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥2800 NIH units/mg protein
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXO8950000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
605195-1000U 04055977188417
605195-100U 04055977188400
605195-5000U 04055977188424

Documentation

Thrombin, Human Plasma, High Activity MSDS

Title

Safety Data Sheet (SDS) 

Thrombin, Human Plasma, High Activity Certificates of Analysis

TitleLot Number
605195

References

Reference overview
Forsberg, G., et al. 1992. J. Protein Chem. 11, 201.
Garcia, J.G. 1992. J. Lab. Clin. Med. 120, 513.
Scarborough, R.M., et al. 1992. J. Biol. Chem. 267, 13146.
Weigel, L.M., et al. 1992. Infect. Immun. 60, 1568.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2008 RFH
DescriptionDesigned for use in thrombin clotting time tests. Serine protease formed in the plasma during the clotting process from prothrombin, calcium, and thromboplasmin. Acts on the soluble plasma protein fibrinogen to convert it to an insoluble fibrin clot. Prepared from homogenous human prothrombin by activation with Factor Xa, Factor Va, and phospholipid. Designed for use in thrombin time tests.
FormLyophilized solid
FormulationLyophilized from 200 mM NaCl, 50 mM sodium citrate, 0.1% PEG-8000, pH 6.5.
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number9002-04-4
RTECSXO8950000
PurityComplete activation from homogeneous prothrombin by SDS-PAGE
Specific activity≥2800 NIH units/mg protein
Unit definitionOne unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.
SolubilityH₂O (1 mg/ml). Solution will have a cloudy appearance.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
Merck USA index14, 9383
ReferencesForsberg, G., et al. 1992. J. Protein Chem. 11, 201.
Garcia, J.G. 1992. J. Lab. Clin. Med. 120, 513.
Scarborough, R.M., et al. 1992. J. Biol. Chem. 267, 13146.
Weigel, L.M., et al. 1992. Infect. Immun. 60, 1568.