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603425 Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem

The Threonine Dehydrogenase Inhibitor, QC1 controls the biological activity of Threonine Dehydrogenase.

Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
403718-45-6C₂₃H₁₆F₃N₃O₂S
Description
OverviewA cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5 µM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10 µM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC50 ~3 µM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM).
Catalogue Number603425
Brand Family Calbiochem®
SynonymsN-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
References
ReferencesAlexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 15828.
Product Information
CAS number403718-45-6
FormWhite powder
Hill FormulaC₂₃H₁₆F₃N₃O₂S
Chemical formulaC₂₃H₁₆F₃N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥96% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
603425 0

Documentation

Threonine Dehydrogenase Inhibitor, QC1 - CAS 403718-45-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Alexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 15828.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-November-2012 JSW
SynonymsN-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
DescriptionA cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5 µM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10 µM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC50 ~3 µM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number403718-45-6
Chemical formulaC₂₃H₁₆F₃N₃O₂S
Structure formulaStructure formula
Purity≥96% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAlexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 15828.