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616458 TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII

616458
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
666729-57-3C₂₁H₂₁NO₄
Description
Overview

This product has been discontinued.



A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC50 = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC50 = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.
Catalogue Number616458
Brand Family Calbiochem®
Synonyms1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
References
ReferencesShimizu, T., et al. 2008. J. Med. Chem. 51, 3326.
Product Information
CAS number666729-57-3
FormOff-white solid
Hill FormulaC₂₁H₂₁NO₄
Chemical formulaC₂₁H₂₁NO₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
616458 0

Documentation

TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem Certificates of Analysis

TitleLot Number
616458

References

Reference overview
Shimizu, T., et al. 2008. J. Med. Chem. 51, 3326.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
DescriptionA cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC50 = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC50 = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number666729-57-3
Chemical formulaC₂₁H₂₁NO₄
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesShimizu, T., et al. 2008. J. Med. Chem. 51, 3326.