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504596 TCN-201 - CAS 852918-02-6 - Calbiochem

TCN-201 - CAS 852918-02-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X

Primary Target: NMDA receptors
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
852918-02-6C₂₁H₁₇ClFN₃O₄S
Description
Overview

This product has been discontinued.



A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
Catalogue Number504596
Brand Family Calbiochem®
Synonyms3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
References
ReferencesBettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
Edman, S., et al. 2012. Neuropharmacology 63, 441.
Hansen, K., et al. 2012. J. Neurosci. 32, 6197.
Product Information
CAS number852918-02-6
FormWhite powder
Hill FormulaC₂₁H₁₇ClFN₃O₄S
Chemical formulaC₂₁H₁₇ClFN₃O₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
504596 0

Documentation

TCN-201 - CAS 852918-02-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
Edman, S., et al. 2012. Neuropharmacology 63, 441.
Hansen, K., et al. 2012. J. Neurosci. 32, 6197.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonyms3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
DescriptionA negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
FormWhite powder
CAS number852918-02-6
Chemical formulaC₂₁H₁₇ClFN₃O₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
Edman, S., et al. 2012. Neuropharmacology 63, 441.
Hansen, K., et al. 2012. J. Neurosci. 32, 6197.