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574661 Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem

The Survivin Antagonist, S12 controls the biological activity of Survivin.

Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one, Survivin Inhibitor II

574661
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
258264-62-9C₁₇H₁₂BrNO₅

Products

Catalogue NumberPackaging Qty/Pack
574661-10MG Sklená flaša 10 mg
Description
OverviewA cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
Catalogue Number574661
Brand Family Calbiochem®
Synonyms3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one, Survivin Inhibitor II
References
ReferencesBerezov, A., et al. 2011. Oncogene 31, 1938.
Product Information
CAS number258264-62-9
FormWhite solid
Hill FormulaC₁₇H₁₂BrNO₅
Chemical formulaC₁₇H₁₂BrNO₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
574661-10MG 04055977189643

Documentation

Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem Certificates of Analysis

TitleLot Number
574661

References

Reference overview
Berezov, A., et al. 2011. Oncogene 31, 1938.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
Synonyms3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one, Survivin Inhibitor II
DescriptionA cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number258264-62-9
Chemical formulaC₁₇H₁₂BrNO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; nearly colorless solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBerezov, A., et al. 2011. Oncogene 31, 1938.