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569615 Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem

The Stem-Cell Factor/c-Kit Inhibitor, ISCK03, also referenced under CAS 945526-43-2, controls the biological activity of Stem-Cell Factor/c-Kit. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II

569615
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
945526-43-2C₁₉H₂₁N₃O₂S
Description
Overview

This product has been discontinued.



A cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 µM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 µM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells. Oral administration of ISCK03 is shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Topical application is likewise demonstrated to decrease UV-induced pigmentation and epidermal melanin level in Brownish guinea pigs in vivo.
Catalogue Number569615
Brand Family Calbiochem®
Synonyms4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II
References
ReferencesNa, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.
Product Information
CAS number945526-43-2
FormDark yellow solid
Hill FormulaC₁₉H₂₁N₃O₂S
Chemical formulaC₁₉H₂₁N₃O₂S
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
569615 0

Documentation

Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem Certificates of Analysis

TitleLot Number
569615

References

Reference overview
Na, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide, SCF/c-Kit Signaling Inhibitor, ISCK03, c-Kit Inhibitor II
DescriptionA cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 µM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 µM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells. Oral administration of ISCK03 is shown to induce hair depigmentation in C57BL/6 mice in a dose-dependent and reversible manner. Topical application is likewise demonstrated to decrease UV-induced pigmentation and epidermal melanin level in Brownish guinea pigs in vivo.
FormDark yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number945526-43-2
Chemical formulaC₁₉H₂₁N₃O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNa, Y.J., et al. 2007. Biochem. Pharmacol. 74, 780.