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573106 STAT3 Inhibitor X, HJB - Calbiochem

The STAT3 Inhibitor X, HJB controls the biological activity of STAT3.

STAT3 Inhibitor X, HJB - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 17-Hydroxy-jolkinolide B, HJB

573106
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₂₆O₅
Description
Overview

This product has been discontinued.



A diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC50= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC50 <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
Catalogue Number573106
Brand Family Calbiochem®
Synonyms17-Hydroxy-jolkinolide B, HJB
References
ReferencesWang, Y., et al. 2009, Canc. Res. 69, 7302.
Product Information
FormOff-white solid
Hill FormulaC₂₀H₂₆O₅
Chemical formulaC₂₀H₂₆O₅
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573106 0

Documentation

STAT3 Inhibitor X, HJB - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor X, HJB - Calbiochem Certificates of Analysis

TitleLot Number
573106

References

Reference overview
Wang, Y., et al. 2009, Canc. Res. 69, 7302.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-September-2010 JSW
Synonyms17-Hydroxy-jolkinolide B, HJB
DescriptionA diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC50= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC50 <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
FormOff-white solid
Chemical formulaC₂₀H₂₆O₅
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWang, Y., et al. 2009, Canc. Res. 69, 7302.